ORIGINAL REPORTS BY AKIHIRO TOJO

 

1. Kimura K, Nanba S, Tojo A, Hirata Y, Matsuoka H, Sugimoto T. Variations in renal arterioles in spontaneously hypertensive rats: Morphometric analysis of afferent and efferent arterioles. Virchows Arch [A] 1989; 415: 565-569.

 

2. Kimura K, Tojo A, Nanba S, Matsuoka H, Sugimoto T. Morphometric analysis of arteriolar diameters in experimental nephropathies: Application of microvascular casts. Virchows Arch [A] 1990, 417: 319-323.

 

3. Tojo A, Kimura K, Nanba S, Matsuoka H, Sugimoto T. Variations in renal arteriolar diameter in deoxycorticosterone acetate-salt hypertensive rats: A microvascular cast study. Virchows Arch [A] 1990; 417: 389-393.

 

4. Tojo A, Nanba S, Kimura K, Hirata Y, Matsuoka H, Sugimoto T, Watanabe N, Ohkubo A. Factitious proteinuria in a young girl. Clin Nephrol 1990; 33: 299-302.

 

5. Kimura K, Tojo A, Nanba S, Matsuoka H, Sugimoto T. Effects of a calcium antagonist on arteriolar diameters in subtotal nephrectomized rats - microvascular cast study. J Clin Electron Microsc 1990; 23: 604-605.

 

6. Namba S, Kimura K, Tojo A, Matsuoka H, Sugimoto T. Effects of antiplatelet agents on glomerular basement membrane anion sites-study in adriamycin-induced nephrotic syndrome in rats. J Clin Electron Microscopy 1990; 23:1078-1079.

 

7. Kimura K, Nanba S, Tojo A, Matsuoka H, Sugimoto T. Effects of Sairei-To on the relapse of steroid-dependent nephrotic syndrome. Am J Chin Med 1990; 18: 45-50.

 

8. Kimura K, Ogawa S, Tojo A, Nanba S, Matsuoka H, Sugimoto T. Effects of a Japanese medical plant on the rat subtotal nephrectomy model: evaluation of its effect by microvascular casts. Am J Chin Med 1990; 18: 167-174.

 

9. Kimura K, Hirata Y, Nanba S, Tojo A, Matsuoka H, Sugimoto T. Effects of arterial natriuretic peptide on renal arterioles: morphometric analysis using microvascular casts. Am J Physiol 1990; 259: F936-F944.

 

10. Kimura K, Nanba S, Tojo A, Matsuoka H, Sugimoto T. Effects of TJ-114 on the progression of renal disease in the subtotally nephrectomized rat. In: Medicines of plants origin in modern therapy. A symposium report (4th World Conference on Clinical Pharmacology, Prague 1989)" Oxford Clinical Communications, Oxford, UK1990; 42-43.

 

11. Kimura K, Tojo A, Matsuoka H, Sugimoto T. Relationship between changes in arteriolar diameters and renal function in antiglomerular basement membrane nephritis-a vascular cast study. J Clin Electron Microscopy 1991; 24:890-891.

 

12. Kimura K, Tojo A, Matsuoka H, Sugimoto T. Effects of antihypertensive drugs on renal damage in rat subtotal nephrectomy model-relation between arteriolar diameters and glomerular sclerosis. J Clin Electron Microscopy 1991; 24:918-919.

 

13. Kimura K, Ogawa S, Watanabe N, Toyota S, Tojo A, Nanba S, Matsuoka H, Ookubo A, Sugimoto T. Immunohistochemical localization of physiological urinary proteins in Wistar rats. Lab Animal Sci 1991; 41:466-470.

 

14. Kimura K, Tojo A, Matsuoka H, Sugimoto T. Renal arteriolar diameters in spontaneously hypertensive rats: vascular cast study. Hypertension 1991; 18: 101-110.

 

15. Sata M, Kimura K, Yagi N, Nanba S, Tojo A, Hirata Y, Matsuoka H, Sugimoto T. A case of membranous nephropathy complicated by interstitial nephritis due to Sjogren's syndrome. J Nephrol 1991; 4: 251-254.

 

16. Endou H, Jung KY, Ota R, Tojo A. Angiotensin II receptor subtypes in rat early proximal tubule. Contrib Nephrol (Cellular Molecular Biology of the Kidney. Basel Karger) 1991; 95: 190-196.

 

17. Tojo A, Kimura K, Matsuoka H, Sugimoto T. Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. J Cardiovasc Pharmacol 1992; 20: 895-899.

 

18. Tojo A, Endou H. Intrarenal handling of proteins in rats using fractional micropuncture technique. Am J Physiol 1992; 263: F601-F606.

 

19. Matsuoka H, Fukui K, Hayakawa H, Suzuki E, Tojo A, Namba S, Atarashi K, Hirata Y, Sugimoto T. Diurnal variation of blood pressure in patients with salt sensitive hypertension. Hypertens Res 1993; 16: 233-237.

 

20. Tojo A, Kimura K, Hirata Y, Matsuoka H, Sugimoto T. Silent lupus nephritis with fingerprint deposits. Intern Med 1993; 32:323-326. (Citation Index: 3)

 

21. Kimura K, Tojo A, Hirata Y, Matsuoka H, Sugimoto T. Morphometric analysis of renal arterioles in subtotally nephrectomize. J Lab Clin Med 1993; 122: 273-283. (Citation Index: 8)

 

22. Tojo A, Gross SS, Zhang L, Tisher CC, Schmidt HHHW, Wilcox CS, Madsen KM. Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney. J Am Soc Nephrol 1994; 4: 1438-1447.

 

23. Tojo A, Guzman NJ, Garg LC, Tisher CC, Madsen KM. Nitric oxide inhibits bafilomycin-sensitive H+-ATPase activity in rat cortical collecting duct. Am J Physiol 1994; 267: F509-F515.

 

24. Tojo A, Tisher CC, Madsen KM. Angiotensin II regulates H+-ATPase activity in rat cortical collecting duct. Am J Physiol 1994; 267: F1045-F1051.

 

25. Doumoto M, Tojo A, Oka K, Numabe A, Yagi S. Acute effects of recombinant human erythropoietin on blood pressure and vasoactive substances in chronic hemodialysis patients. Dokkyo J Med Sci 1994; 21: 163-170.

 

26. Kimura K, Tojo A, Hirata Y, Goto A, Omata M. Effects of calcium antagonist and an angiotensin II receptor antagonist on rat renal arterioles. Blood Pressure 1994; 3 (supple 5): 71-74.

 

27.Tojo A, Madsen KM, Wilcox CS. Expression of immunoreactive nitric oxide synthase isoforms in rat kidney. effect of dietary salt and losartan. Jpn Heart J 1995; 36:389-398.

 

28. Kimura K, Nagai R, Sakai T, Aikawa M, Kuro-o M, Kobayashi N, Inagami T, Oshi M, Suzuki N, Oba S, Mise N, Tojo A, Hirata Y, Goto A, Yazaki Y, Omata M. Diversity and variability of smooth muscle phenotypes of renal arterioles as revealed by myosin isoform expression. Kidney Int 1996; 48: 372-382.

 

29. Tojo A, Doumoto M, Oka K, Numabe A, Kimura K, Yagi S. Endothelin-mediated effect of erythropoietin on blood pressure and renal hemodynamics in hypertensive rats. Am J Physiol 1996; 270: R744-R748.

 

30. Takanohashi A, Tojo A, Kobayashi N, Yagi S, Matsuoka H. Effects of trichlormethiazide and captopril on nitric oxide synthase activity in the kidney of deoxycorticosterone acetate-salt hypertensive rats. Jpn Heart J 1996; 37(2): 251-259.

 

31. Tojo A, Kobayashi N, Kimura K, Hirata Y, Matsuoka H, Yagi S, Omata M. Effects of antihypertensive drugs on nitric oxide synthase activity in rat kidney. Kidney Int 1996; 49 (Suppl. 55): S138-S140.

 

32. Kimura K, Suzuki N, Ohba S, Nagai R, Hiroi J, Mise N, Tojo A, Nagaoka A, Hirata Y, Goto A, Yazaki Y, Omata M. Hypertensive glomerular damage as revealed by the expression of a-smooth muscle actin and non-muscle myosin. Kidney Int 1996; 49 (Suppl. 55): S169-S172.

 

33. Hirata Y, Hayakawa H, Kakoki M, Tojo A, Suzuki E, Kimura K, Goto A, Kikuchi K, Nagano T, Hirobe M, Omata M. Nitric oxide release from kidneys of hypertensive rats treated with imidapril. Hypertension, 1996; 27 [part 2]: 672-678.

 

34. Hiroi J, Kimura K, Aikawa M, Tojo A, Suzuki Y, Nagamatsu T, Omata M, Yazaki Y, Nagai R. Expression of a nonmuscle myosin heavy chain in glomerular cells differentiates various types of glomerular disease in rats. Kidney Int 1996; 49: 1231-1241.

 

35. Suzuki J, Isobe M, Aikawa M, Kawauchi M, Shiojima I, Kobayashi N, Tojo A, Kimura K, Nishikawa T, Sakai T, Sekiguchi M, Yazaki Y, Nagai R. Nonmuscle and smooth muscle myosin heavy chain expression in rejected cardiac allograft- a study in rat and monkey models. Circulation 1996; 94: 1118-1124.

 

36.Ohba S, Kimura K, Mise N, Konno Y, Suzuki N, Miyashita K, Tojo A, Hirata Y, Uehara Y, Atarashi K, Goto A, Omata M. Differential localization of s and e antigens in hepatitis B virus-associated glomerulonephritis. Clin Nephrol 1997; 48: 44-47.

 

37. Bremer V, Tojo A, Kimura K, Hirata Y, Goto A, Nagamatsu T, Suzuki Y, Omata M. Role of nitric oxide in rat nephrotoxic nephritis: comparison between inducible and constitutive nitric oxide synthase. J Am Soc Nephrol 1997; 8: 1712-1721.

 

38. Tojo A, Welch WJ, Bremer V, Kimoto M, Kimura K, Omata M, Ogawa T, Vallance P, Wilcox CS. Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney. Kidney Int 1997; 52:1593-1601.

 

39. Hirata Y, Hayakawa H, Kakoki M, Tojo A, Suzuki E, Nagata D, Kimura K, Goto A, Kikuchi K, Nagano T, Hirobe M, Omata M. Receptor subtype for vasopressin-induced release of nitric oxide from rat kidney. Hypertension 1997; 29: 58-64.

 

40. Suzuki N, Kimura K, Nagai R, Ohba S, Mise N, Hiroi J, Tojo A, Hirata Y, Nagaoka A, Goto A, Omata M. Hypertensive renal damage: Modulation expression of smooth muscle myosin heavy chain isoforms. Nephrology 1997; 3(3):251-259.

 

41. Kimura K, Suzuki N, Ohba S, Mise N, Miyashita K, Tojo A, Goto A, Omata M. Effects of amlodipine, a calcium channel blocker, on rat renal arterioles. Curr Ther Res 1997; 58: 375-380.

 

42. Kimura K, Inokuchi S, Sugaya T, Suzuki N, Yoneda H, Shirato I, Mise N, Oba S, Miyashita K, Tojo A, Hirata Y, Goto A, Sakai T, Murakami K, Omata M. Localization and action of angiotensin II type 1 receptor in the renal microcirculation. Kidney Int 1997; 52 (Suppl 63): S201-S204.

 

43. Mise N, Kimura K, Nagai R, Ohba S, Suzuki N, Miyashita K, Tojo A, Goto A, Omata M. Mesangial expression of a nonmuscle myosin heavy chain, SMemb, is associated with glomerular sclerosis and a predictor of prognosis in IgA nephropathy. Nephron 1998; 78: 284-289.

 

44. Oba S, Kimura K, Suzuki N, Mise N, Tojo A, Miyashita K, Konno Y, Hirata Y, Goto A, Omata M. Relevance of periglomerular myofibroblasts in progression of human glomerulonephritis. Am J Kidney Dis 1998, 32: 419-425.

 

45. Kimura K, Suzuki N, Mise N, Ohba S, Miyashita K, Tojo A, Hirata Y, Goto A, Omata M: Effects of the beta-adrenoceptor blocker nipradilol on renal microcirculation in a rat model: A comparative study with propranolol. Curr Ther Res 1998, 59: 179-186.

 

46. Kimura K, Suzuki N, Mise N, Oba S, Miyashita K, Tojo A, Hirata Y, Goto A, Omata M: Effects of barnidipine hydrochloride, a calcium channel blocker, on renal microcriculation in rats: A pilot study. Curr Ther Res 1998, 59:826-834.

 

47. Tojo A, Sekine T, Nakajima N, Hosoyamada M, Kanai Y, Kimura K, Endou H. Immunohistochemical localization of multispecific renal organic anion transporter in rat kidney. J Am Soc Nephrol 1999; 10: 464-471.

 

48. Kakoki M, Hirata Y, Hayakawa H, Tojo A, Nagata D, Suzuki E, Kimura K, Goto A, Kikuchi K, Nagano T, Omata M. Effects of hypertension, diabetes mellitus, and hypercholesterolemia on endothelin type B receptor-mediated nitric oxide release from rat kidney. Circulation 1999, 99: 1242-1248.

 

49. Tojo A, Bredt DS, Wilcox CS. Distribution of postsynaptic density proteins in rat kidney: Relationship to neuronal nitric oxide synthase. Kidney Int 1999, 55: 1384-1394.

 

50. Welch WJ, Tojo A, Lee JU, Kang DG, Schnakenberg CG, Wilcox CS. Nitric oxide synthase in the JGA of the SHR: expression and role in tubuloglomerular feedback. Am J Physiol 1999, 277: F130-F138.

 

51. Kobayashi N, Yanaka H, Tojo A, Kobayashi K, Matsuoka H. Effects of amlodipine on nitric oxide synthase mRNA expression and coronary microcirculation in prolonged nitric oxide blockade-induced hypertensive rats. J Cardiovasc Pharmacol 1999, 34: 173-181.

 

52. Honda S, Kashiwagi M, Ookata K, Tojo A, Hirose S. Regulation by 1, 25 dihydroxyvitamin D3 of expression of stanniocalcin messages in the rat kidney and ovary. FEBS Lett 1999, 459: 119-122.

 

53. Takeda M, Tojo A, Sekine T, Hosoyamada M, Kanai Y, Endou H. Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. Kidney Int 1999, 56: 2128-2136.

 

54. Kimura K, Suzuki N, Mise N, Oba S, Miyashita K, Kamijo A, Tojo A, Hirata Y, Goto A, Omata M: Vasodilating effects of celiprolol, a beta-adrenoceptor blocker, on renal microcirculation in rats. Curr Ther Res 1999, 60: 31-36.

 

55. Kakoki M, Hirata Y, Hayakawa H, Suzuki E, Nagata D, Tojo A, Nishimatsu H, Nakanishi N, Hattori Y, Kikuchi K, Nagano T, Omata M. Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure. J Am Soc Nephrol 2000, 11: 301-309.

 

56. Nakajima N, Sekine T, Cha S H, Tojo A, Hosoyamada M, Kanai Y, Yan K, Awa S, Endou H. Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney. Kidney Int 2000, 57: 1608-1616.

 

57. Welch WJ, Tojo A, Wilcox CS. Roles of NO and oxygen radicals in tubuloglomerular feedback in SHR. Am J Physiol 2000, 278: F769-F776.

 

58. Ookata K, Tojo A, Suzuki Y, Nakamura N, Kimura K, Wilcox CS, Hirose S. Localization of inward rectifier potassium channel kir7.1 in the basolateral membrane of distal nephron and collecting duct. J Am Soc Nephrol 2000; 11:1987-1994.

 

59. Tojo A, Kimoto M, Wilcox CS. Renal expression of constitutive NOS and DDAH: separate effects of salt intake and angiotensin. Kidney Int 2000; 58:2075-2083.

 

60. Onozato ML, Tojo A, Kamijo A, Taniguchi S, Kimura K, Goto A, Fujita T. Tubulointerstitial nephritis associated with acute intermittent porphyria. Clin Nephrol 2001; 55: 171-174.

 

61. Narumi S, Onozato ML, Tojo A, Sakamoto S, and Tamatani T. Tissue-specific induction of E-selectin in glomeruli is augmented following diabetes mellitus. Nephron 2001; 89:161-171.

 

62. Tojo A, Onozato ML, Ha H, Kurihara H, Sakai T, Goto A, Fujita T, Endou H. Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats. Histochem Cell Biol 2001; 116:269-276.

 

63. Ookata K, Tojo A, Onozato ML, Kasiwagi M, Honda S, Hirose S. Distribution of stanniocalcin 1 in the apical membranes of the distal nephron of rat kidney and its regulation by vitamin D3. Exp Nephrol 2001; 9: 428-435.

 

64. Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H. Characterization of ochratoxin A transport by human organic anion transporters. Life Sci 2001; 69:2123-2135.

 

65. Onozato ML, Tojo A, Goto A, Fujita T, Wilcox CS. Oxidative stress and NOS in rat diabetic nephropathy: Effects of ACEI and ARB. Kidney Int 2002; 61:186-194.

 

66. Chabrashvili T, Tojo A, Onozato ML, Kitiyakara C, Quinn MT, Fujita T, Welch WJ, Wilcox CS. Expression and Cellular Localization of Classic NADPH Oxidase Subunits in the Spontaneously Hypertensive Rat Kidney. Hypertension 2002; 39:269-274.

 

67. Jung KY, Takeda M, Shimoda M, Narikawa S, Kim DK, Tojo A, Sekine T, Endou H: Role of organic anion transporter 3 (OAT3) in cephaloridine-induced nephrotoxicity. Life Sci 2002; 70: 1861-1874.

 

68. Babu E, Takeda M, Narikawa S, Kobayashi Y, Enomoto A, Tojo A, Cha SH, Sekine T, Sakthisekaran D, Endou H. Characterization of ochratoxin A transport by human organic anion transporter 4. Biochim Biophys Acta 2002; 1590: 64-75.

 

69. Enomoto A, Takeda M, Tojo A, Sekine T, Cha SH, Takayama F, Niwa T, Endou H: Role of organic anion transporters in the uptake and toxicity of indoxyl sulfate. J Am Soc Nephrol 2002; 13:1711-1720.

 

70. Mise N, Kimura K, Kurabayashi M, Nagai R, Okuda T, Ohba S, Suzuki N, Miyashita K, Kamijo A, Tojo A, Goto A, Omata M. Angiotensin II Enhances Glomerular Expression of a Nonmuscle Myosin Heavy Chain, SMemb, with Extracellular Matrix Accumulation. Nephron 2002; 90:477-483.

                            

71. Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D, Hayakawa H, Satonaka H, SataM, Tojo A, Suzuki E, Kangawa K, Matsuo H, Kitamura T, Nagai R.                                                                                               Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene. Circ Res 2002; 90:657-63.

                             

72. Sata M, Saiura A, Kunisato A, Tojo A, Okada S, Tokuhisa T, Hirai H, Makuuchi M, Hirata Y, Nagai R. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med. 2002; 8:403-409.

 

73. Tojo A, Onozato ML, Kobayashi N, Goto A, Matsuoka H, Fujita T. Angiotensin II and Oxidative Stress in Dahl Salt-Sensitive Rat With Heart Failure. Hypertension 2002; 40: 834-839.

 

74. Tojo, A Fujita T, Wilcox CS. Omapatrilat: still a promise in salt-sensitive hypertension? J Hypertens 2003; 21:31-32.

 

75. Ueno T, Kaname S, Takaichi K, Nagase M, Tojo A, Onozato ML, Fujita T. Lox-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats. Hypertens Res 2003; 26:117-122.

 

76. Onozato ML, Tojo A, Goto A, Fujita T. Effect of combination therapy with dipyridamole and quinapril in diabetic nephropathy. Diabetes Res Clin Pract 2003; 59:83-92.

77. Khamdang S, Takeda M, Babu E, Noshiro R, Onozato ML, Tojo A, Enomoto A, Huang XL, Narikawa S, Anzai N, Piyachaturawat P, Endou H. Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003; 465:1-7.

 

78. Yamasaki M, Kawai J, Nakaoka T, Ogita T, Tojo A, Fujita T. Adrenomedullin overexpression to inhibit cuff-induced arterial intimal formation. Hypertension. 2003; 41:302-7.

 

79. Tojo A, Onozato ML, Kurihara H, Sakai T, Goto A, Fujita T. Angiotensin II Blockade Restores Albumin Reabsorption in Proximal Tubule of Diabetic Rat. Hypertens Res 2003; 26:413-419.

 

80. Onozato ML, Tojo A, Ogura S, Asaba K, Goto A, Fujita T. Primary amyloidosis with multiple pulmonary nodular lesions and IgA nephropathy-like renal involvement. Clin Nephrol 2003; 60: 134-138.

 

81. Asaba K, Tojo A, Onozato ML, Mimura N, Kido M, Goto A, Endo H, Fujita T. Fibrillary glomerulonephritis associated with essential thrombocytosis. Clin Exp Nephrol 2003; 7:296-300.

 

82. Alebouyeh M, Takeda M, Onozato ML, Tojo A, Noshiro R, Hasannejad H, Inatomi J, Narikawa S, Huang XL, Khamdang S, Anzai N, Endou H. Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites. J Pharmacol Sci 2003; 93:430-436.

 

83.Takeda M, Noshiro R, Onozato ML, Tojo A, Hasannejad H, Huang XL, Narikawa S, Endou H. Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors. Eur J Pharmacol. 2004;483:133-138.

 

84. Hasannejad H, Takeda M, Taki K, Jung SH, Babu E, Jutabha P, Khamdang S, Aleboyeh M, Onozato ML, Tojo A, Enomoto A, Anzai N, Narikawa S, Huang XL, Niwa T, Endou H. Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004;308:1021-1029.

 

85. Onozato ML, Tojo A, Goto A, Fujita T. Radical scavenging effect of gliclazide in diabetic rats fed with a high cholesterol diet. Kidney Int 2004; 65:951-960.

 

86. Miyashita K, Tojo A, Kimura K, Goto A, Omata M, Nishiyama K, Fujita T. Blood pressure response to erythropoietin injection in hemodialysis and predialysis patients. Hypertens Res 2004; 27:79-84.

 

87. Kawai J, Ando K, Tojo A, Shimosawa T, Takahashi K, Onozato ML, Yamasaki M, Ogita T, Nakaoka T, Fujita T. Endogenous Adrenomedullin Protects Against Vascular Response to Injury in Mice. Circulation 2004; 109:1147-1153.

 

88. Tojo A, Onozato ML, Fukuda S*, Asaba K, Kimura K, Fujita T. Nitric oxide generated by nNOS in the macula densa regulates the afferent arteriolar diameter in rat kidney. Med Electr Microscop 2004; 37: 236-241.

 

89. Hasannejad H, Takeda M, Narikawa S, Huang XL, Enomoto A, Taki K, Niwa T, S Jung SH, Onozato ML, Tojo A, Endou H. Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs. Eur J Pharmcol 2004; 499:45-51.

 

90. Chander PN, Gealekman O, Brodsky SV, Elitok S, Tojo A, Crabtree M, Gross SS, Goligorsky MS. Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen.

J Am Soc Nephrol. 2004; 15:2391-2403.

 

91. Tojo A, Onozato ML, Kobayashi N, Goto A, Matsuoka H, Fujita T. Antioxidative Effect of P38 Mitogen-Activated Protein Kinase Inhibitor in the Kidney of Hypertensive Rat. J Hypertens. 2005; 23:165-174.

 

92. Onozato ML, Tojo A. Role of NADPH oxidase in hypertension and diabetic nephropathy. Curr Hypertens Rev 2005; 1:15-20.

 

93. Asaba K, Tojo A, Onozato ML, Goto A, Quinn MT, Fujita T, Wilcox CS. Effects of NADPH oxidase inhibitor in diabetic nephropathy. Kidney Int 2005; 67:1890-1898.

 

94. Kobayashi N, Hara K, Tojo A, Onozato ML, Honda T, Yoshida K, Mita S, Tsubokou Y, Matsuoka H. Eplerenone shows renoprotective effect by reducing LOX-1 mediated adhesion molecule, PKC -MAPK-p90RSK, and Rho-kinase pathway. Hypertension 2005;45:538-544.

 

95. Tagawa H, Kizuka Y, Ikeda T, Itoh S, Kawasaki N, Kurihara H, Onozato ML, Tojo A, Sakai T, Kawasaki T, Oka S. Non-sulfated form of the HNK-1 carbohydrate is expressed in mouse kidney. J Biol Chem 2005; 280 (25):23876-23883.

 

96. Nishi H, Shibagaki Y, Hatakeyama S, Ito T, Nagata T, Ohno M, Tojo A, Nangaku M, Fujita T. Metastatic intracranial subdural empyema from renal cyst infection in autosomal dominant polycystic kidney disease. Nephrol Dial Transplant 2005; 20 (12):2820-2823.

 

97. Tojo A, Onozato ML, Fujita T. Role of macula densa neuronal nitric oxide synthase in renal diseases. Med Mol Morphol. 2006 Mar;39(1):2-7.

 

98. Tojo A, Onozato ML, Asaba K, Fujita T. Spironolactone with ACE inhibitor is effective in gross hematuria of nephroptosis. Int J Urol 2006; 13:990-992.

 

99. Tojo A, Onozato ML, Fujita T. Repeated subileus due to angioedema during renin-angiotensin system blockade. Am J Med Sci 2006; 332:36-38.

 

100. Nilwarangkoon S, Anzai N, Shiraya K, Yu E, Islam R, Cha SH, Onozato ML, Miura D, Jutabha P, Tojo A, Kanai Y, Endou H. Role of Mouse Organic Anion Transporter 3 (mOat3) as a Basolateral Prostaglandin E(2) Transport Pathway. J Pharmacol Sci. 2007; Jan;103(1):48-55.

 

101. Asaba K, Tojo A, Onozato ML, Goto A, Fujita T. Double-edged action of SOD mimetic in diabetic nephropathy. J Cardiovasc Pharmacol 2007; 49(1):13-19.

 

102. Nishi H, Tojo A, Onozato ML, Jimbo R, Nangaku M, Uozaki H, Hirano K, Isayama H, Omata M, Kaname S, Fujita T. Anti-carbonic anhydrase II antibody in autoimmune pancreatitis and tubulointerstitial nephritis. Nephrol Dial Transplant 2007; 22(4):1273-1275.

 

103. Onozato ML, Tojo A, Kobayashi N, Goto A, Matsuoka H, Fujita T. Dual blockade of aldosterone and angiotensin II additively suppresses TGF- and NADPH oxidase in the hypertensive kidney. Nephrol Dial Transplant 2007;22;1314-1322.

 

104. Tojo A, Asaba K. Onozato ML. Suppressing renal NADPH oxidase to treat diabetic nephropathy. Expert Opin Ther Targets. 2007 11(8):1011-1018.

 

105. Wang D, Gill PS, Chabrashvili T, Onozato ML, Raggio J, Mendonca M, Dennehy K, Li M, Modlinger P, Leiper J, Vallance P, Adler O, Leone A, Tojo A, Welch WJ, Wilcox CS. Isoform-Specific Regulation by NG-NG-Dimethylarginine Dimethylaminohydrolase of Rat Serum Asymmetric Dimethylarginine and Vascular Endothelium-Derived Relaxing Factor/NO. Circ Res 2007; 101(6):627-635.

 

106. Onozato ML, Tojo A, Leiper J, Fujita T, Palm F, Wilcox CS. Expression of NG,NG-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney: Effects of Angiotensin II Receptor Blockers. Diabetes 2008; 57:172-180.

 

107. Mimura I, Tojo A, Uozaki H, Fujita T. Erythrophagocytosis by renal tubular cells. Kidney Int 2008; 74, 398.

 

108. Kido M, Ando K, Onozato ML, Tojo A, Yoshikawa M, Ogita T, Fujita T. Protective effect of dietary potassium against vascular injury in salt-sensitive hypertension. Hypertension. 2008 Feb;51(2):225-31.

 

109. Yokoyama H, Anzai N, Ljubojevic M, Ohtsu N, Sakata T, Miyazaki H, Nonoguchi H, Islam R, Onozato M, Tojo A, Tomita K, Kanai Y, Igarashi T, Sabolic I, Endou H. Functional and Immunochemical Characterization of a Novel Organic Anion Transporter Oat8 (Slc22a9) in Rat Renal Collecting Duct. Cell Physiol Biochem. 2008;21(4):269-278.

 

110. Tojo A, Onozato ML, Asaba K, Fujita T. How to optimize the treatment of a hypertensive patient with multiple cardiovascular risk factors. Renin Angiotensin System in Cardiovascular Medicine. 2008;4(2):16-18.

 

111. Mimura I, Hori Y, Matsukawa H, Uozaki H, Tojo A, Fujita T. Noncrescentic ANCA-associated renal crisis in systemic sclerosis. Clin Nephrol 2008; 70:183-185.

 

112. Tojo A, Onozato ML, Kitiyakara C, Kinugasa S, Fukuda S, Sakai T, Fujita T. Glomerular albumin filtration through podocyte cell body in puromycin aminonucleoside nephritic rat. Medical Molecular Morphology 2008; 41 (2) 92-98.

 

113. Asaba K, Tojo A, Onozato ML, Kinugasa S, Miyazaki H, Miyashita K, Uehara Y, Hirata Y, Kimura K, Goto A, Omata M, Fujita T. Long-term renal prognosis of IgA nephropathy with therapeutic trend shifts. Intern Med 2009; 48(11):883-890

 

114. Unuma K, Tojo A, Harada K, Saka K, Nakajima M, Ishii T, Fujita T, Yoshida K. Autopsy report on pseudo-Bartter syndrome with renal calcification induced by diuretics and diet pills. BMJ Case Reports doi: 10.1136/bcr.12.2008.1380 (Published 25 May 2009)

 

115. Mimura I, Tojo A, Kinugasa S, Uozaki H, Fujita T. Renal cell carcinoma in association with IgA nephropathy in the elderly. Am J Med Sci. 2009; 338(5):431-432.

 

116. Tojo A. Optical Coherence Tomography in the Kidney: A Step Toward Echo Microscopy. J Urol 2010; 183:1669-1670

 

117. Tojo A, Unuma K, Harada K, Yoshida K, Fujita T. Localization and mechanism of nephrocalcinosis in pseudo-Bartter’s syndrome. Kidney Int. 2010; 77:831.

 

118. Kinugasa S, Tojo A, Sakai T, Fujita T. Silver-enhanced immunogold scanning electron microscopy using vibratome sections of rat kidney: detection of albumin filtration and reabsorption. Med Mol Morphol 2010; 43:218-225.

 

119. Katsuyuki Ando, Hiroshi Ohtsu, Yoshihiro Arakawa, Kiyoshi Kubota, Takuhiro Yamaguchi, Miki Nagase, Akira Yamada, Toshiro Fujita, on behalf of the EVALUATE Study Investigators. Rationale and design of the Eplerenone combination Versus conventional Agents to Lower blood pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial: a double-blinded randomized placebo-controlled trial to evaluate the antialbuminuric effects of an aldosterone blocker in hypertensive patients with albuminuria. Hypertens Res 2010; 33(6):616-621.

 

120. Hanamura K, Tojo A, Kinugasa S, Asaba K, Onozato ML, Uozaki H, Fukayama M, Fujita T. Detection of myeloperoxidase in membranous nephropathy-like deposits in patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. Human Pathology 2011; 42:649-658.

 

121. Kinugasa S, Tojo A, Sakai T, Tsumura H, Takahashi M, Hirata Y, Fujita T. Selective albuminuria via podocyte albumin transport in puromycin nephrotic rats is attenuated by an inhibitor of NADPH oxidase. Kidney Int 2011; 80: 1328–1338.

 

122. Tojo A, Kinugasa S. Mechanisms of glomerular albumin filtration and tubular reabsorption. Int J Nephrol 2012; Volume 2012, Article ID 481520, 9 pages, doi:10.1155/2012/481520

 

123. Hirahashi J, Jo A, Ueda K, Tojo A, Fujita T. Successful treatment of antineutrophil cytoplasmic antibody-associated vasculitis with eicosapentaenoic acid. Ann Intern Med 2012; 156(10):755-756. doi: 10.1059/0003-4819-156-10-201205150-00023

 

124. Ikeda Y, Nangaku M, Ishibashi Y, Hirohama D, Uozaki H, Tojo A, Ishikawa A, Fujita T. A case of de novo focal segmental glomerulosclerosis occurred one and half years after kidney transplantation supposed to be caused by calcineurin inhibitor. Clin Transplant 2012;26(suppl 24):76-80. doi: 10.1111/j.1399-0012.2012.01640.x.

 

125. Miyazaki H, Uozaki H, Tojo A, Hirashima S, Inaga S, Sakuma K, Morishita Y, Fukayama M. Application of low-vacuum scanning electron microscopy for renal biopsy specimens. Pathol Res Pract. 2012 Sep 15;208(9):503-9.

doi: 10.1016/j.prp.2012.05.006. Epub 2012 Jul 15.

 

126. Tojo A, Miyashita K, Kinugasa S, Takemura T, Goto A. Acute Tubulointerstitial Nephritis with an Autoantibody Response Against Carbonic Anhydrase II. Am J Med Sci. 2013; 345(5):407-408. doi: 10.1097/MAJ.0b013e318272f1a6..

 

127. Parving HH, Brenner BM, McMurray JJV, de Zeeuw D, Haffner SM, Solomon SD, Chaturvedi N, Persson F, Desai AS, Nicolaides M,ALTITUDE Investigators. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. New Engl J Med 2012; 367(23):2201-2213.

 

128. Sasaki M, Tojo A, Okochi Y, Miyawaki N, Kamimura D, Yamaguchi A, Murakami M, Okamura Y. Autoimmune disorder phenotypes in HVCN1 gene deficient mice. Biochem J. 2013; 450:295-301. doi: 10.1042/BJ20121188.

 

129. Hanamura K, Tojo A, Kinugasa S, Asaba K, Fujita T. The resistive index is a marker of renal function, pathology, prognosis, and responsiveness to steroid therapy in chronic kidney disease patients. International Journal of Nephrology. Volume 2012, Article ID 139565, 9 pages, doi: 10.1155/2012/139565. Epub 2012 Dec 16.

 

130. Tojo A. Paraneoplastic glomerulopathy associated with renal cell carcinoma. Chapter 7 in the Renal Tumor, Edited by Jindong Chen, ISBN 978-953-51-0981-5, Publisher: InTech, Published: February 13, 2013 under CC BY 3.0 license
DOI: 10.5772/56083, InTechOpen, 2013, (http://dx.doi.org/10.5772/53534)

 

131. Michio Hayashi, Akihiro Tojo, Tatsuo Shimosawa, Toshiro Fujita. The Role of Adrenomedullin in the Renal NADPH Oxidase and (Pro)renin in Diabetic Mice. J Diabetes Res. 2013;2013:134395. doi: 10.1155/2013/134395. Epub 2013 Jul 15.

 

132. Hanamura K, Tojo, A, FujitaT. Urinary and glomerular podocytes in patients with chronic kidney diseases. Clin. Exp. Nephrol 2014;18(1):95-103. DOI 10.1007/s10157-013-0814-8

 

133. Tojo A. The role of the kidney in protein metabolism: the capacity of tubular lysosomal proteolysis in nephrotic syndrome. Kidney Int 2013; 84:861-863. Doi:10.1038/ki.2013.284

 

134. Tojo A. Doppler ultrasonography and hypertensive target organ damage. Anadolu Kardiyol Derg 2014;14: doi:10.5152/akd.2013.12677

 

135. Hirahashi J, Kawahata K, Arita M, Iwamoto R, Hishikawa K, Honda M, Hamasaki Y, Tanaka T, Okuba K, Takase O, Nakakuki M, Saigo K, Suzuki K, Kawachi S, Tojo A, Seki G, Marumo T, Hayashi M, Fujita T. Immunomodulation with eochosapentaenoic acid supports the treatment f autoimmune small-vessel vasculitis. Sci Rep. 2014 Sep 18;4:6406. doi: 10.1038/srep06406.

 

136. Ando K, Ohtsu H, Uchida S, Kaname S, Arakawa Y, Fujita T; EVALUATE Study Group. Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic hypertensive patients with albuminuria: a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol. 2014 Dec;2(12):944-53. PMID: 25466242

 

137. Tojo A, Hatakeyama S, Kinugasa S, Nangaku M. Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2015:8 103–113. doi: 10.2147/DMSO.S78771. eCollection 2015. PMID: 25709483

 

138. Saito H, Hamasaki Y, Tojo A, Shintani Y, Shimizu A, Nangaku M. Phospholipase A2 receptor positive membranous nephropathy long after living donor kidney transplantation between identical twins. Nephrology 2015;20(suppl. 2):101-104. doi: 10.1111/nep.12458. (Citation index: 0) PMID: 26031599

 

139. Tojo A, Asaba K, Kinugasa S, Ikeda Y, Shintani Y, Fukayama M, Nangaku M. The reduced expression of proximal tubular transporters in acquired Fanconi syndrome with k light chain deposition. Med Mol Morphol 2016; 49(1):48-52. doi: 10.1007/s00795-015-0114-3. Epub 2015 Jul 4. PMID: 26141649

 

140. Tojo A, Kinugasa S, Fujita T, Wilcox CS. A local renal renin-angiotensin system activation via renal uptake of prorenin and angiotensinogen in diabetic rats. Diabetes Metab Syndr Obes. 2016 Jan 18;9:1-10. doi: 10.2147/DMSO.S91245. eCollection 2016. PMID: 26848273

 

141. Rikako Oki, Masanori Kono, Kanae Kubo, Akihiro Tojo, Kazuhiko Yamamoto. Urinary phagocytic macrophages in hemophagocytic lymphohistiocytosis. Kidney Int 2016; 90:908. doi: 10.1016/j.kint.2016.07.023. PMID: 27633873

 

142. Sugawara Y, Honda K, Katagiri D, Nakamura M, Kawakami T, Nasu R, Shintani Y, Tojo A, Kurokawa M, Fukayama M, Nangaku M. Umbilical cord blood transplantation associated nephrotic syndrome successfully treated by low-density lipoprotein apheresis. Intern Med 2016; 55(19):2831-2836. DOI: 10.2169/internalmedicine.55.7017 PMID: 27725544

 

143. Akihiro Tojo, Saaya Hatakeyama, Satoshi Kinugasa, Satoru Fukuda, Toshio Sakai. Enhanced podocyte vesicle transport in the nephrotic rat. Med Mol Morphol. 2017; 50(2):86-93. Mar 17. doi: 10.1007/s00795-016-0151-6. [Epub ahead of print]PMID: 28314927

 

144. Takehiro Ohira, Toshihiko Ishimitsu, Akihisa Yabe, Masahito Furuichi, Yasuhiko Ueno, Shou Onoda, Akihiko Nagasa, Yoshiki Murayama, Hiroshi Satonaka, Akihiro Tojo. Comparisons of increasing calcium channel blocker dose and adding thiazide diuretic in hypertensive patients given medium-dose angiotensin II receptor blocker and amlodipine. Dokkyo Journal of Medical Sciences 2017; 44(3):209-216.

 

145. Akihiro Tojo, Saaya Hatakeyama, Masaomi Nangaku, Toshihiko Ishimitsu. H+-ATPase blockade reduced renal gluconeogenesis and plasma glucose in a diabetic rat model. Med Mol Morphol. 2018;51(2):89-96. DOI 10.1007/s00795-017-0175-6

 

146. Yoshiki Murayama, Mayu Uchida, Akihiro Tojo, Toshihiko Ishimitsu. Electron microscopy of urinary sediments in Fabry disease. Kidney Int. 2018 Oct;94(4):834. doi: 10.1016/j.kint.2018.04.010. 

 

147. Akihiko Nagase, Toshihiko Ishimitsu, Masahito Furuichi, Shou Onoda, Takehiro Ohira, Yoshiki Murayama, Akihiro Tojo. Comparisons of Effects of Allopurinol and Febuxostat in Chronic Hemodialysis Patients. Dokkyo Journal of Medical Sciences 2019; 46(1):17-27.

 

148. Akihiro Tojo. Mechanism underlying selective albuminuria in minimal change nephrotic syndrome. Int J Nephrol 2019; Article ID 5859102, 8 pages. https://doi.org/10.1155/2019/5859102

 

149. Tojo, A, Yokoyama S, Ohira T, Hatakeyama S, Satonaka H, Ishimitsu T. MECHANISM OF SELECTIVE ALBUMINURIA IN MINIMAL CHANGE NEPHROTIC SYNDROME. ISN WCN 2019 Abstract. Kidney Int Reports 2019; 4, S153.

 

150. Ohira T, Tojo A, Yokoyama S, Kaiga A, Hirao J, Furuichi M, Nagase A, Murayama Y, Satonaka H, Ishimitsu T. RELATIONSHIP BETWEEN URINARY PODOCYTES AND URINARY PROTEIN FRACTION EVALUATED BY SDS-PAGE. ISN WCN 2019 Abstract. Kidney Int Reports 2019; 4, S304.

 

151. Uematsu-Uchida M, Ohira T, Tomita S, Satonaka H, Tojo A, Ishimitsu T. Rituximab in treatment of anti-GBM antibody glomerulonephritis.

Medicine (Baltimore). 2019 Nov;98(44):e17801. doi:10.1097/MD.0000000000017801.PMID: 31689860 

 

152. Hirao J, Tojo A, Hatakeyama S, Satonaka H, Ishimitsu T. V-ATPase blockade reduces renal gluconeogenesis and improves insulin secretion in type 2 diabetic rats.

Hypertens Res. 2020; 43:1079-1088. doi: 10.1038/s41440-020-0450-0. [Epub ahead of print] PMID:32382157

​

153. Akira Ishimitsu, Akihiro Tojo, Hiroshi Satonaka, Toshihiko Ishimitsu. Eucommia ulmoides (Tochu) and its extract geniposidic acid reduced blood pressure and improved renal hemodynamics. Biomed Pharmacother 2021 Jul 15;141:111901. doi: 10.1016/j.biopha.2021.111901. Online ahead of print.PMID: 34328117.

 

154. Hatakeyama S, Tojo A, Satonaka H, Yamada NO, Senda T, Ishimitsu T. Decreased Podocyte Vesicle Transcytosis and Albuminuria in APC C-Terminal Deficiency Mice with Puromycin-Induced Nephrotic Syndrome.

Int J Mol Sci. 2021 Dec 14;22(24):13412. doi: 10.3390/ijms222413412.

 

155. Ishimitsu A, Satonaka H, Furuichi M, Murayama Y, Tojo A, Ishimitsu T. Role of circulating endothelial progenitors in responsivemess to erythropoiesis-stimulating agents in hemodialysis patients. Ren Replace Ther 7:57, 2021.

 

156. Abe M, Furuichi M, Ishimitsu T, Tojo A. Analysis of purple urine bag syndrome by low vacuum scanning electron microscopy. Med Mol Morphol. 2022; 55:123-130. doi: 10.1007/s00795-022-00313-0. Online ahead of print

 

157. Akira Ishimitsu, Akihiro Tojo, Jun Hirao, Shohei Yokoyama, Takehiro Ohira, Yoshiki Murayama, Toshihiko Ishimitsu, Dedong Kang, Kazuho Honda, Takashi Ehara, Kazuyuki Ishida and Yoshihiko Ueda. AL-Kappa Primary Amyloidosis with Apolipoprotein A-IV Deposition. Intern Med 61: 871-876, 2022.  doi: 10.2169/internalmedicine.7955-21

 

158. Akiko Kaiga, Toshihiko Ishimitsu, Hiroshi Satonaka, Yoshio Iwashima, Akihiro Tojo. Therapeutic effects of allopurinol and topiroxostat in chronic kidney disease patients with hyperuricemia. Dokkyo Journal of Medical Sciences 48(3):171-181, 2022.
 

159. Makoto Abe, Akiko Kaiga, Takehiro Ohira, Toshihiko Ishimitsu, Akihiro Tojo. Urinary podocyte excretion predicts urinary protein selectivity and renal prognosis. International Journal of Nephrology Volume 2022, Article ID 2702651, 11 pages https://doi.org/10.1155/2022/2702651

160. Haruna Arakawa, Shohei Yokoyama, Takehiro Ohira, Dedong Kang, Kazuho Honda, Yoshihiko Ueda, and Akihiro Tojo. Juvenile Membranous Nephropathy developed after Human Papillomavirus (HPV) Vaccination. Vaccines 2022, 10(9), 1442; https://doi.org/10.3390/vaccines10091442

 

161. Honda T, Ishimitsu T, Satonaka H, Iwashima Y, Tojo A. Therapeutic effects of a selective mineralocorticoid receptor blocker as an additional combination antihypertensive drug in hypertensive patients. Dokkyo Med J 1(3):226-234, 2022.

 

162. Yuka Sato, Makoto Abe, Akihiko Nagase, Takehiro Ohira, Yoshiki Murayama, Toshihiko Ishimitsu, Akihiro Tojo. Relationship between Cyclical Fluctuations in Renal Disease and Trends in Infectious Diseases. Dokkyo Medical Journal 1(4): 327-336, 2022. DOI https://doi.org/10.51040/dkmj.2022-035

 

163. Sei Saitoh, Takashi Takaki, Kazuki Nakajima, Bao Wo, Hiroshi Terashima, Satoshi Shimo, Huy Bang Nguyen, Truc Quynh Thai, Kanako Kumamoto, Kazuo Kunisawa, Shizuko Nagao, Akihiro Tojo, Nobuhiko Ohno, Kazuo Takahashi. Treatment of tubular damage in high-fat-diet-fed obese mice using sodium-glucose co-transporter inhibitors. PLOS ONE https://doi.org/10.1371/journal.pone.0281770 February 13, 2023
 

164. Akihiro Tojo, Makoto Abe, Kin-ichi Matsuyama. Direct observation of epoxy resin blocks for renal biopsy by low-vacuum scanning electron microscopy. Medical Molecular Morphology 56: 206-216, 2023. https://link.springer.com/article/10.1007/s00795-023-00356-x

 

165. Akiko Kaiga, Yuka Sato, Haruna Arakawa, Tatemitsu Rai, Akihiro Tojo. Crescentic glomerulonephritis associated with syphilis: a case report and review of literature. Journal of Medical Case Reports 17:549, 2023. https://doi.org/10.1186/s13256-023-04293-2

 

166. Shohei Yokoyama, Akihiro Tojo. Comparison of the therapeutic effects on the renal and life prognosis in ANCA-associated nephritis. Dokkyo Medical Journal, 2023; 2(4):281-288. doi.org/10.51040/dkmj.2023-006

 

167. Haruna Arakawa, Makoto Abe, Yuka Sato, Tatemitsu Rai, Akihiro Tojo. Early mortality after the initiation of hemodialysis in elderly patients. Dokkyo Medical Journal 2024;3(1):42-50, https://doi.org/10.51040/dkmj.2023-037.

 

168. Kana Unuma, Shuheng Wen, Sho Sugahara, Shutaro Nagano, Toshihiko Aki, Tadayuki Ogawa, Shino Takeda-Homma, Masakazu Oikawa, Akihiro Tojo

Thallium reabsorption via NKCC2 causes severe acute kidney injury with outer medulla-specific calcium crystal casts in rats. Arch Toxicol 2024;98(12):3973-3986. doi: 10.1007/s00204-024-03868-2. https://link.springer.com/article/10.1007/s00204-024-03868-2